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Upstream signaling through PI3K/AKT, MAPK (ERK/JNK/p38), and PKC further enhances Nrf2 stabilization and transcriptional activity

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However, no difference in iAUC was observed between SSTR5a alone and SSTR5a + DPP-4i ( P = 0.3), but upon mixed effects analysis, a significant difference between the 2 groups was observed at time 15 minutes ( P = 0.004)